It is subjective to determine the best creation or invention of man, as it depends on individual perspectives and opinions. Here are some widely considered significant creations or inventions:

  1. The Wheel: The wheel revolutionized transportation and commerce by enabling people to move goods and people more efficiently.

  2. The Printing Press: The printing press made it possible to mass produce books, increasing literacy and access to knowledge.

  3. Electricity: Electricity transformed the world by powering homes and businesses, and enabling the development of new technologies such as the computer and the internet.

  4. The Internet: The internet has dramatically changed the way people communicate, access information, and do business, creating a global network of information and knowledge.

  5. The Microprocessor: The microprocessor has revolutionized the way we process and store information, enabling the development of personal computers, smartphones, and other digital devices.

  6. Antibiotics: Antibiotics have saved countless lives by treating bacterial infections and reducing mortality rates from diseases such as tuberculosis and pneumonia.

  7. Clean Energy Sources: Clean energy sources such as solar and wind power have the potential to reduce our dependence on fossil fuels and mitigate the impact of climate change.

This list is by no means exhaustive, and other inventions such as the telephone, airplane, and automobile have also had a significant impact on the world. Ultimately, the best creation or invention of man is a matter of personal interpretation and perspective.